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Biomedical Journal Apr 2020Science and commerce advance together and the stem cell field is no exception. With the promise of cures for conditions as diverse as cancer, autism, neural... (Review)
Review
Science and commerce advance together and the stem cell field is no exception. With the promise of cures for conditions as diverse as cancer, autism, neural degeneration, organ replacement and addiction, long-term preservation of dental stem cells is a growth market. The discovery nearly twenty years ago, of viable, multipotent, stem cells in dental pulp from both baby and adult teeth initiated, and drives, this market.The dental stem cell preservation services, "tooth banks", focus on the collection of a child's baby teeth, as they are shed naturally, and storage of the stem cells from within the pulp for therapeutic use in later years should the child require them. This review focuses on the procedures related to these stem cell storage services and may serve as an introduction for many to the practice of "tooth banking".
Topics: Cell Differentiation; Cell Proliferation; Dental Offices; Humans; Mesenchymal Stem Cells; Tissue Banks; Tooth, Deciduous
PubMed: 32381462
DOI: 10.1016/j.bj.2020.02.003 -
Archives of Pathology & Laboratory... Mar 2011The increasing number of requests for use of clinically archived tissue in translational research poses unique challenges. Conflicts may arise between pathologists who...
CONTEXT
The increasing number of requests for use of clinically archived tissue in translational research poses unique challenges. Conflicts may arise between pathologists who are responsible for overseeing and preserving the tissues and investigators who need these materials for research purposes.
OBJECTIVES
To evaluate the status of our institution's Tissue Registry Archive and to develop updated written policies and procedures to support a new modern and robust tracking system with features of a library loan system.
DESIGN
An observational study was performed.
RESULTS
We found the existing process for managing loans of tissue (slides and paraffin blocks) to be insufficient for the complexity and volume of this task. After extensive customization, a new tracking system was implemented in January 2008. Analysis of the first year of the system's use (2008) showed that of the 206,330 slides and 51,416 blocks loaned out in 2008, 92% and 94%, respectively, were returned by the due date. These rates were markedly improved from those before the new system: 61% and 47%, respectively, in 2005. Material permanently "lost" in 2008 represented only 0.02% of slides and 0.05% of blocks, none of which was the only diagnostic material for the case.
CONCLUSIONS
With expanding needs for archived tissues for clinical care and growing demands for translational research, it is essential that pathology departments at institutions with large tissue-based research endeavors have a tracking and management system in place to meet clinical, educational, and research needs, as well as legal requirements.
Topics: Conflict, Psychological; Humans; Pathology; Policy Making; Registries; Tissue Banks; Translational Research, Biomedical
PubMed: 21366459
DOI: 10.5858/2010-0044-SA.1 -
CA: a Cancer Journal For Clinicians 1982
Topics: Breast; Breast Neoplasms; Female; Humans; Nipples; Surgery, Plastic; Tissue Banks
PubMed: 6804039
DOI: 10.3322/canjclin.32.3.187 -
Genomics, Proteomics & Bioinformatics Aug 2019Neuropsychiatric disorders affect hundreds of millions of patients and families worldwide. To decode the molecular framework of these diseases, many studies use human... (Review)
Review
Neuropsychiatric disorders affect hundreds of millions of patients and families worldwide. To decode the molecular framework of these diseases, many studies use human postmortem brain samples. These studies reveal brain-specific genetic and epigenetic patterns via high-throughput sequencing technologies. Identifying best practices for the collection of postmortem brain samples, analyzing such large amounts of sequencing data, and interpreting these results are critical to advance neuropsychiatry. We provide an overview of human brain banks worldwide, including progress in China, highlighting some well-known projects using human postmortem brain samples to understand molecular regulation in both normal brains and those with neuropsychiatric disorders. Finally, we discuss future research strategies, as well as state-of-the-art statistical and experimental methods that are drawn upon brain bank resources to improve our understanding of the agents of neuropsychiatric disorders.
Topics: Brain; China; High-Throughput Nucleotide Sequencing; Humans; Mental Disorders; Tissue Banks
PubMed: 31811942
DOI: 10.1016/j.gpb.2019.02.002 -
Neuroscience Bulletin Apr 2019Advances in cellular and molecular biology underpin most current therapeutic advances in medicine. Such advances for neurological and neurodegenerative diseases are... (Review)
Review
Advances in cellular and molecular biology underpin most current therapeutic advances in medicine. Such advances for neurological and neurodegenerative diseases are hindered by the lack of similar specimens. It is becoming increasingly evident that greater access to human brain tissue is necessary to understand both the cellular biology of these diseases and their variation. Research in these areas is vital to the development of viable therapeutic options for these currently untreatable diseases. The development and coordination of human brain specimen collection through brain banks is evolving. This perspective article from the Sydney Brain Bank reviews data concerning the best ways to collect and store material for different research purposes.
Topics: Aging; Biomedical Research; Brain; Humans; Neurodegenerative Diseases; Tissue Banks; Tissue Preservation
PubMed: 30604281
DOI: 10.1007/s12264-018-0326-3 -
Future Oncology (London, England) Dec 2016
Topics: Databases, Genetic; Humans; Pancreatic Neoplasms; Research; Tissue Banks
PubMed: 27541064
DOI: 10.2217/fon-2016-0243 -
Neuroscience Bulletin Apr 2019
Topics: Brain; China; Humans; Tissue Banks
PubMed: 30843142
DOI: 10.1007/s12264-019-00350-3 -
Frontiers in Endocrinology 2021Over the last two decades, increased interest of scientists to study bone marrow adiposity (BMA) in relation to bone and adipose tissue physiology has expanded the... (Review)
Review
Over the last two decades, increased interest of scientists to study bone marrow adiposity (BMA) in relation to bone and adipose tissue physiology has expanded the number of publications using different sources of bone marrow adipose tissue (BMAT). However, each source of BMAT has its limitations in the number of downstream analyses for which it can be used. Based on this increased scientific demand, the International Bone Marrow Adiposity Society (BMAS) established a Biobanking Working Group to identify the challenges of biobanking for human BMA-related samples and to develop guidelines to advance establishment of biobanks for BMA research. BMA is a young, growing field with increased interest among many diverse scientific communities. These bring new perspectives and important biological questions on how to improve and build an international community with biobank databases that can be used and shared all over the world. However, to create internationally accessible biobanks, several practical and legislative issues must be addressed to create a general ethical protocol used in all institutes, to allow for exchange of biological material internationally. In this position paper, the BMAS Biobanking Working Group describes similarities and differences of patient information (PIF) and consent forms from different institutes and addresses a possibility to create uniform documents for BMA biobanking purposes. Further, based on discussion among Working Group members, we report an overview of the current isolation protocols for human bone marrow adipocytes (BMAds) and bone marrow stromal cells (BMSCs, formerly mesenchymal), highlighting the specific points crucial for effective isolation. Although we remain far from a unified BMAd isolation protocol and PIF, we have summarized all of these important aspects, which are needed to build a BMA biobank. In conclusion, we believe that harmonizing isolation protocols and PIF globally will help to build international collaborations and improve the quality and interpretation of BMA research outcomes.
Topics: Adipose Tissue; Adiposity; Biological Specimen Banks; Bone Marrow; Humans; Tissue Banks
PubMed: 34646237
DOI: 10.3389/fendo.2021.744527 -
Biopreservation and Biobanking Oct 2015
Topics: Biomedical Research; Humans; Tissue Banks; Tissue and Organ Procurement
PubMed: 26484569
DOI: 10.1089/bio.2015.29031.hmm -
BMJ Open Ophthalmology Nov 2022One of the barriers to increasing the number of eye donors and transplants is the lack of an integrated, real-time clinical workflow platform with capabilities to secure...
BACKGROUND
One of the barriers to increasing the number of eye donors and transplants is the lack of an integrated, real-time clinical workflow platform with capabilities to secure interface with external systems. It is well understood that costly inefficiencies exist in the current fragmented donation and transplantation ecosystem: systems operate in silos without seamless sharing of key data. A modern, interoperable digital system can directly increase the number of eyes procured and transplanted.
METHODS
We hypothesize that the use of the comprehensive iTransplant™ platform increases the number of eyes procured and transplanted. The platform is a modern web-based system which provides comprehensive workflow coverage for eye banking, advanced communication tools, a portal for eye surgeons to submit requests, and secure digital interfaces with external systems such as hospital EMRs, medical examiner/coroner case management systems, and laboratory LIS systems. With these interfaces, referrals, hospital charts and test results are received securely in real-time.
RESULTS
At over 80 tissue and eye banks in the United States, the use of iTransplant™ has led to a significant increase in referrals and eyes transplanted. Over a period of 19 months in 1 hospital system, during which the only major process change was the adoption of the iReferral™ electronic interface to automate donor referrals, the annualized average shows a 46% increase in referrals and a 15% increase in tissue/eye donors. Over the same time period, the integration with lab systems saved over 1,400 hours of staff time and increased patient safety by eliminating manual transcription of lab results.
CONCLUSIONS
Continued successful results are achieved internationally in increasing the number of procured and transplanted eyes as a result of: (1) the automated, seamless, and electronic receipt of referrals and donor data by eye banks in their iTransplant™ Platform, (2) the elimination of manual data transcription, and (3) the increase in the quality and timeliness of patients' data being available to donation and transplantation professionals.
Topics: Humans; United States; Tissue and Organ Procurement; Ecosystem; Tissue Donors; Eye Banks; Corneal Transplantation
PubMed: 37282704
DOI: 10.1136/bmjophth-2022-EEBA.15